From an interview with Industrial Biotechnology:
We are missing fundamental biological knowledge, and the fact that you can't get a grant from the government to study unknown genes makes it very limiting for the future. I think that going forward most of the advances in science will be coming from the biotech industry, and the applications in industry, rather than from academia.
He's a bit reductionist here but I would say 90% correct. In academia, incentives are fundamentally misaligned for the future. I see that getting worse going forward and, in a nutshell (with lots of color about how people are treated and who benefits overlaid), is why I left.